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MGP002152

UniProt Annotations

Entry Information
Gene Nameornithine decarboxylase 1
Protein EntryDCOR_HUMAN
UniProt IDP11926
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-ornithine = putrescine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Enzyme RegulationInhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3. {ECO:0000269|PubMed:17900240}.
FunctionKey enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. {ECO:0000269|PubMed:17900240}.
InductionDown-regulated in response to enterovirus 71 (EV71) infection (at protein level). {ECO:0000269|PubMed:16548883}.
PathwayAmine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
PtmS-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. {ECO:0000269|PubMed:10462479, ECO:0000269|PubMed:11461922}.
SimilarityBelongs to the Orn/Lys/Arg decarboxylase class-II family. {ECO:0000305}.
SubunitMonomer. Does not form an heterodimer with AZIN2 (By similarity). Homodimer. {ECO:0000250}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/odc1/";
Web ResourceName=Wikipedia; Note=Ornithine decarboxylase entry; URL="http://en.wikipedia.org/wiki/Ornithine_decarboxylase";
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