MGP Database

MGP002155

Ontology/Pathway Information

Entrez Gene ID	4967
Gene Name	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Gene Symbol	OGDH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005759	TAS:Reactome	C	mitochondrial matrix
GO:0031966	ISS:UniProtKB	C	mitochondrial membrane
GO:0005739	IDA:HPA	C	mitochondrion
GO:0045252	IBA:GO_Central	C	oxoglutarate dehydrogenase complex
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0034602	IEA:Ensembl	F	oxoglutarate dehydrogenase (NAD+) activity
GO:0004591	ISS:UniProtKB	F	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976	IEA:InterPro	F	thiamine pyrophosphate binding
GO:0006103	IEA:Ensembl	P	2-oxoglutarate metabolic process
GO:0044237	TAS:Reactome	P	cellular metabolic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0021695	IEA:Ensembl	P	cerebellar cortex development
GO:0006091	ISS:UniProtKB	P	generation of precursor metabolites and energy
GO:0006096	IEA:UniProtKB-KW	P	glycolytic process
GO:0021766	IEA:Ensembl	P	hippocampus development
GO:0006554	TAS:Reactome	P	lysine catabolic process
GO:0006734	IEA:Ensembl	P	NADH metabolic process
GO:0061034	IEA:Ensembl	P	olfactory bulb mitral cell layer development
GO:0021860	IEA:Ensembl	P	pyramidal neuron development
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0021756	IEA:Ensembl	P	striatum development
GO:0006104	IEA:Ensembl	P	succinyl-CoA metabolic process
GO:0022028	IEA:Ensembl	P	tangential migration from the subventricular zone to the olfactory bulb
GO:0021794	IEA:Ensembl	P	thalamus development
GO:0006099	TAS:Reactome	P	tricarboxylic acid cycle

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_1785	Citric acid cycle (TCA cycle)
REACT_1298	Lysine catabolism
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_1046	Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111083	The citric acid (TCA) cycle and respiratory electron transport

SMP Pathway Links

SMP ID	Description
SMP00549	2-ketoglutarate dehydrogenase complex deficiency
SMP00057	Citric Acid Cycle
SMP00546	Congenital lactic acidosis
SMP00547	Fumarase deficiency
SMP00548	Mitochondrial complex II deficiency
SMP00551	Pyruvate dehydrogenase deficiency (E2)
SMP00550	Pyruvate dehydrogenase deficiency (E3)
SMP00654	Warburg Effect