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MGP002155

UniProt Annotations

Entry Information
Gene Nameoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Protein EntryODO1_HUMAN
UniProt IDQ02218
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02218-1; Sequence=Displayed; Name=2; IsoId=Q02218-2; Sequence=VSP_042313; Note=Probably insensitive to calcium.; Name=3; IsoId=Q02218-3; Sequence=VSP_043628, VSP_043629; Note=No experimental confirmation available.;
Catalytic Activity2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Enzyme RegulationCalcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity. {ECO:0000269|PubMed:24495017}.
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence CautionSequence=BAA01393.1; Type=Frameshift; Positions=1003; Evidence={ECO:0000305}; Sequence=BAA06836.1; Type=Frameshift; Positions=1003; Evidence={ECO:0000305};
SimilarityBelongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
Web ResourceName=Wikipedia; Note=Alpha-ketoglutarate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Alpha-ketoglutarate_dehydrogenase";
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