MGP Database

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MGP002162

UniProt Annotations

Entry Information
Gene Nameopioid receptor, kappa 1
Protein EntryOPRK_HUMAN
UniProt IDP41145
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P41145-1; Sequence=Displayed; Name=2; IsoId=P41145-2; Sequence=VSP_055313; Note=No experimental confirmation available.;
FunctionG-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
InteractionQ9H0R8:GABARAPL1; NbExp=5; IntAct=EBI-925028, EBI-3464833;
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
SubunitInteracts with SLC9A3R1. Interacts with GABARAPL1. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:22437504}.
Tissue SpecificityDetected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Web ResourceName=Wikipedia; Note=Kappa opioid receptor entry; URL="http://en.wikipedia.org/wiki/Kappa_opioid_receptor";
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