MGP Database

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MGP002195

Ontology/Pathway Information

Entrez Gene ID5054
Gene Nameserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene Symbol SERPINE1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031012 IDA:BHF-UCLCextracellular matrix
GO:0005576 IDA:BHF-UCLCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0002020 IPI:UniProtKBFprotease binding
GO:0005102 IPI:BHF-UCLFreceptor binding
GO:0004867 IDA:BHF-UCLFserine-type endopeptidase inhibitor activity
GO:0001525 IEP:UniProtKBPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0071222 IMP:BHF-UCLPcellular response to lipopolysaccharide
GO:0001300 IEP:BHF-UCLPchronological cell aging
GO:0050829 IGI:BHF-UCLPdefense response to Gram-negative bacterium
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0042730 TAS:ReactomePfibrinolysis
GO:0010467 TAS:ReactomePgene expression
GO:0030195 IC:BHF-UCLPnegative regulation of blood coagulation
GO:0033629 IDA:BHF-UCLPnegative regulation of cell adhesion mediated by integrin
GO:0030336 IDA:BHF-UCLPnegative regulation of cell migration
GO:0010951 IDA:BHF-UCLPnegative regulation of endopeptidase activity
GO:2000352 IMP:BHF-UCLPnegative regulation of endothelial cell apoptotic process
GO:1902042 IMP:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051918 IDA:BHF-UCLPnegative regulation of fibrinolysis
GO:0010757 IDA:BHF-UCLPnegative regulation of plasminogen activation
GO:2000098 IDA:BHF-UCLPnegative regulation of smooth muscle cell-matrix adhesion
GO:0014912 IDA:BHF-UCLPnegative regulation of smooth muscle cell migration
GO:0061044 IGI:BHF-UCLPnegative regulation of vascular wound healing
GO:0061045 IC:BHF-UCLPnegative regulation of wound healing
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0045766 IMP:BHF-UCLPpositive regulation of angiogenesis
GO:0030194 IMP:BHF-UCLPpositive regulation of blood coagulation
GO:0050729 IGI:BHF-UCLPpositive regulation of inflammatory response
GO:0032757 IMP:BHF-UCLPpositive regulation of interleukin-8 production
GO:0035491 IMP:BHF-UCLPpositive regulation of leukotriene production involved in inflammatory response
GO:0090026 IMP:BHF-UCLPpositive regulation of monocyte chemotaxis
GO:0048260 IDA:BHF-UCLPpositive regulation of receptor-mediated endocytosis
GO:0045944 TAS:ReactomePpositive regulation of transcription from RNA polymerase II promoter
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0010469 IDA:BHF-UCLPregulation of receptor activity
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_24941Circadian Clock
REACT_116125Disease
REACT_641Dissolution of Fibrin Clot
REACT_163906ECM proteoglycans
REACT_118779Extracellular matrix organization
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_604Hemostasis
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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