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MGP002195

UniProt Annotations

Entry Information
Gene Nameserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Protein EntryPAI1_HUMAN
UniProt IDP05121
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05121-1; Sequence=Displayed; Name=2; IsoId=P05121-2; Sequence=VSP_045493; Note=No experimental confirmation available.;
DiseaseNote=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
DiseasePlasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. {ECO:0000269|PubMed:9207454}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionSerine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. {ECO:0000269|PubMed:15853774}.
InteractionP02763:ORM1; NbExp=4; IntAct=EBI-953978, EBI-976767;
PtmInactivated by proteolytic attack of the urokinase-type (u- PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
SimilarityBelongs to the serpin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitForms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. {ECO:0000269|PubMed:11384978, ECO:0000269|PubMed:7522053}.
Tissue SpecificityFound in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/serpine1/";
Web ResourceName=Wikipedia; Note=Plasminogen activator inhibitor-1 entry; URL="http://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1";
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