MGP Database

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MGP002206

Ontology/Pathway Information

Entrez Gene ID5091
Gene Namepyruvate carboxylase
Gene Symbol PC
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005743 IEA:EnsemblCmitochondrial inner membrane
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:HPACmitochondrion
GO:0005524 TAS:ProtIncFATP binding
GO:0009374 TAS:ProtIncFbiotin binding
GO:0004075 IEA:InterProFbiotin carboxylase activity
GO:0003677 IEA:InterProFDNA binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004736 TAS:ReactomeFpyruvate carboxylase activity
GO:0006768 TAS:ReactomePbiotin metabolic process
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0006094 TAS:ReactomePgluconeogenesis
GO:0006006 TAS:ReactomePglucose metabolic process
GO:0006629 IEA:UniProtKB-KWPlipid metabolic process
GO:0006107 IEA:EnsemblPoxaloacetate metabolic process
GO:0006090 IEA:EnsemblPpyruvate metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11153Biotin transport and metabolism
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_1520Gluconeogenesis
REACT_723Glucose metabolism
REACT_264090Glycogen storage diseases
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_264430Myoclonic epilepsy of Lafora
SMP Pathway Links
SMP IDDescription
SMP005492-ketoglutarate dehydrogenase complex deficiency
SMP00055Alanine Metabolism
SMP00057Citric Acid Cycle
SMP00546Congenital lactic acidosis
SMP00562Fructose-1,6-diphosphatase deficiency
SMP00547Fumarase deficiency
SMP00128Gluconeogenesis
SMP00581Glycogenosis, Type IA. Von gierke disease
SMP00573Glycogenosis, Type IB
SMP00574Glycogenosis, Type IC
SMP00374Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
SMP00313Lactic Acidemia
SMP00196Leigh Syndrome
SMP00548Mitochondrial complex II deficiency
SMP00560Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)
SMP00558Primary hyperoxaluria II, PH2
SMP00352Primary Hyperoxaluria Type I
SMP00350Pyruvate Carboxylase Deficiency
SMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212Pyruvate Dehydrogenase Complex Deficiency
SMP00551Pyruvate dehydrogenase deficiency (E2)
SMP00550Pyruvate dehydrogenase deficiency (E3)
SMP00559Pyruvate kinase deficiency
SMP00060Pyruvate Metabolism
SMP00466Transfer of Acetyl Groups into Mitochondria
SMP00563Triosephosphate isomerase
SMP00654Warburg Effect
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