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MGP002216

Record overview

MGPD IDMGP002216
Gene ID5111
SpeciesHomo sapiens (Human)
Gene Nameproliferating cell nuclear antigen
Gene Symbol PCNA
SynonymsATLD2;
Alternate namesproliferating cell nuclear antigen; DNA polymerase delta auxiliary protein; cyclin;
Chromosome20
Map Location20pter-p12
SummaryThe protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PCNA

Proteins

proliferating cell nuclear antigen
Refseq ID:NP_872590
Protein GI:33239451
UniProt ID:P12004
mRNA ID:NM_182649
Length:261
RefSeq Status:
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLA
LVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMN
EPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
 
proliferating cell nuclear antigen
Refseq ID:NP_002583
Protein GI:4505641
UniProt ID:P12004
mRNA ID:NM_002592
Length:261
RefSeq Status:
Protein sequence is identical to GI:33239451 (mRNA isoform)
 
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