MGP Database

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MGP002216

Ontology/Pathway Information

Entrez Gene ID5111
Gene Nameproliferating cell nuclear antigen
Gene Symbol PCNA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:MGICcentrosome
GO:0005737 IDA:HPACcytoplasm
GO:0005663 TAS:UniProtKBCDNA replication factor C complex
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0043596 IDA:BHF-UCLCnuclear replication fork
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:MGICnucleus
GO:0043626 IBA:GO_CentralCPCNA complex
GO:0070557 IDA:UniProtKBCPCNA-p21 complex
GO:0032139 IDA:BHF-UCLFdinucleotide insertion or deletion binding
GO:0070182 IPI:UniProtKBFDNA polymerase binding
GO:0030337 IBA:GO_CentralFDNA polymerase processivity factor activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0032405 IDA:HGNCFMutLalpha complex binding
GO:0000701 IDA:BHF-UCLFpurine-specific mismatch base pair DNA N-glycosylase activity
GO:0030971 IPI:UniProtKBFreceptor tyrosine kinase binding
GO:0006284 TAS:ReactomePbase-excision repair
GO:0008283 TAS:ProtIncPcell proliferation
GO:0006281 TAS:ReactomePDNA repair
GO:0006271 TAS:ReactomePDNA strand elongation involved in DNA replication
GO:0030855 IEP:UniProtKBPepithelial cell differentiation
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0007507 IEA:EnsemblPheart development
GO:0006272 IBA:GO_CentralPleading strand elongation
GO:0006298 IDA:BHF-UCLPmismatch repair
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0006289 TAS:ReactomePnucleotide-excision repair
GO:0006297 TAS:ReactomePnucleotide-excision repair, DNA gap filling
GO:0032077 IDA:UniProtKBPpositive regulation of deoxyribonuclease activity
GO:0006275 IEA:InterProPregulation of DNA replication
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0033993 IEA:EnsemblPresponse to lipid
GO:0000723 TAS:ReactomePtelomere maintenance
GO:0000722 TAS:ReactomePtelomere maintenance via recombination
GO:0032201 TAS:ReactomePtelomere maintenance via semi-conservative replication
GO:0006283 TAS:ReactomePtranscription-coupled nucleotide-excision repair
GO:0019985 IDA:UniProtKBPtranslesion synthesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1104Base Excision Repair
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_22172Chromosome Maintenance
REACT_216DNA Repair
REACT_383DNA Replication
REACT_932DNA strand elongation
REACT_471E2F mediated regulation of DNA replication
REACT_8030Extension of Telomeres
REACT_111214G0 and Early G1
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_1998Gap-filling DNA repair synthesis and ligation in GG-NER
REACT_74Gap-filling DNA repair synthesis and ligation in TC-NER
REACT_2253Global Genomic NER (GG-NER)
REACT_312Lagging Strand Synthesis
REACT_1838Leading Strand Synthesis
REACT_264442Mismatch Repair
REACT_264347Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
REACT_264501Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
REACT_21267Mitotic G1-G1/S phases
REACT_1826Nucleotide Excision Repair
REACT_1792Polymerase switching
REACT_7987Polymerase switching on the C-strand of the telomere
REACT_8027Processive synthesis on the C-strand of the telomere
REACT_1385Processive synthesis on the lagging strand
REACT_2192Removal of DNA patch containing abasic residue
REACT_70Removal of the Flap Intermediate
REACT_7999Removal of the Flap Intermediate from the C-strand
REACT_1993Repair synthesis for gap-filling by DNA polymerase in TC-NER
REACT_378Repair synthesis of patch ~27-30 bases long by DNA polymerase
REACT_1893Resolution of Abasic Sites (AP sites)
REACT_1128Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_7961Telomere C-strand (Lagging Strand) Synthesis
REACT_7970Telomere Maintenance
REACT_1628Transcription-coupled NER (TC-NER)
SMP Pathway Links
SMP IDDescription
SMP00478Nucleotide Excision Repair
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