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MGP002221

UniProt Annotations

Entry Information
Gene Nameproprotein convertase subtilisin/kexin type 2
Protein EntryNEC2_HUMAN
UniProt IDP16519
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P16519-1; Sequence=Displayed; Name=2; IsoId=P16519-2; Sequence=VSP_043358; Note=No experimental confirmation available.; Name=3; IsoId=P16519-3; Sequence=VSP_045873; Note=No experimental confirmation available.;
Catalytic ActivityRelease of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
FunctionInvolved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269|PubMed:9287128}.
Sequence CautionSequence=CAA21069.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB89428.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB96732.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase S8 family. Furin subfamily. {ECO:0000305}.
SimilarityContains 1 peptidase S8 domain. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
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