MGP Database

MGP002280

Ontology/Pathway Information

Entrez Gene ID	5270
Gene Name	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Gene Symbol	SERPINE2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:BHF-UCL	C	cytosol
GO:0031012	IDA:BHF-UCL	C	extracellular matrix
GO:0005576	IDA:BHF-UCL	C	extracellular region
GO:0005615	IBA:GO_Central	C	extracellular space
GO:0031232	IDA:BHF-UCL	C	extrinsic component of external side of plasma membrane
GO:0031594	ISS:BHF-UCL	C	neuromuscular junction
GO:0031091	IMP:BHF-UCL	C	platelet alpha granule
GO:0031982	IDA:UniProtKB	C	vesicle
GO:0005539	IDA:BHF-UCL	F	glycosaminoglycan binding
GO:0008201	IDA:BHF-UCL	F	heparin binding
GO:0005102	IPI:BHF-UCL	F	receptor binding
GO:0004867	IDA:BHF-UCL	F	serine-type endopeptidase inhibitor activity
GO:0007596	IEA:Ensembl	P	blood coagulation
GO:0021683	IEA:Ensembl	P	cerebellar granular layer morphogenesis
GO:0050974	IEA:Ensembl	P	detection of mechanical stimulus involved in sensory perception
GO:0060384	IEA:Ensembl	P	innervation
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0042628	IEA:Ensembl	P	mating plug formation
GO:0030195	IDA:BHF-UCL	P	negative regulation of blood coagulation
GO:0030308	IEA:Ensembl	P	negative regulation of cell growth
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0010951	IBA:GO_Central	P	negative regulation of endopeptidase activity
GO:0014067	IEA:Ensembl	P	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0010757	IMP:BHF-UCL	P	negative regulation of plasminogen activation
GO:0090331	ISS:BHF-UCL	P	negative regulation of platelet aggregation
GO:0042177	IEA:Ensembl	P	negative regulation of protein catabolic process
GO:0010955	IC:BHF-UCL	P	negative regulation of protein processing
GO:0045861	IDA:BHF-UCL	P	negative regulation of proteolysis
GO:0045879	IEA:Ensembl	P	negative regulation of smoothened signaling pathway
GO:0010766	IEA:Ensembl	P	negative regulation of sodium ion transport
GO:0048711	IDA:BHF-UCL	P	positive regulation of astrocyte differentiation
GO:0030334	NAS:UniProtKB	P	regulation of cell migration
GO:0051966	IEA:Ensembl	P	regulation of synaptic transmission, glutamatergic
GO:0048505	IEA:Ensembl	P	regulation of timing of cell differentiation
GO:0032940	IEA:Ensembl	P	secretion by cell
GO:0033363	IEA:Ensembl	P	secretory granule organization
GO:0061108	IEA:Ensembl	P	seminal vesicle epithelium development

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_1439	Common Pathway
REACT_641	Dissolution of Fibrin Clot
REACT_2051	Formation of Fibrin Clot (Clotting Cascade)
REACT_604	Hemostasis
REACT_326	Intrinsic Pathway