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MGP Database

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MGP002283

UniProt Annotations

Entry Information

Gene Name	phosphatidylinositol glycan anchor biosynthesis, class C
Protein Entry	PIGC_HUMAN
UniProt ID	Q92535
Species	Human

Comments

Comment type	Description
Catalytic Activity	UDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
Function	Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity	Belongs to the PIGC family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Subunit	Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.
Web Resource	Name=Functional Glycomics Gateway - GTase; Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C8; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_556";