MGP Database

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MGP002292

Ontology/Pathway Information

Entrez Gene ID5293
Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene Symbol PIK3CD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0042629 TAS:GOCCmast cell granule
GO:0005942 NAS:UniProtKBCphosphatidylinositol 3-kinase complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0016303 NAS:UniProtKBF1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:GO_CentralF1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0035004 TAS:UniProtKBFphosphatidylinositol 3-kinase activity
GO:0046934 IBA:GO_CentralFphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0002250 TAS:UniProtKBPadaptive immune response
GO:0042113 TAS:UniProtKBPB cell activation
GO:0035754 TAS:UniProtKBPB cell chemotaxis
GO:0001782 IEA:EnsemblPB cell homeostasis
GO:0050853 TAS:UniProtKBPB cell receptor signaling pathway
GO:0001816 TAS:UniProtKBPcytokine production
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0002551 TAS:UniProtKBPmast cell chemotaxis
GO:0043303 TAS:UniProtKBPmast cell degranulation
GO:0060374 TAS:UniProtKBPmast cell differentiation
GO:0030101 TAS:UniProtKBPnatural killer cell activation
GO:0035747 TAS:UniProtKBPnatural killer cell chemotaxis
GO:0001779 TAS:UniProtKBPnatural killer cell differentiation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030593 TAS:UniProtKBPneutrophil chemotaxis
GO:0072672 TAS:UniProtKBPneutrophil extravasation
GO:0014065 TAS:UniProtKBPphosphatidylinositol 3-kinase signaling
GO:0036092 NAS:GOCPphosphatidylinositol-3-phosphate biosynthetic process
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0006468 NAS:UniProtKBPprotein phosphorylation
GO:0002679 TAS:UniProtKBPrespiratory burst involved in defense response
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042110 TAS:UniProtKBPT cell activation
GO:0010818 TAS:UniProtKBPT cell chemotaxis
GO:0030217 TAS:UniProtKBPT cell differentiation
GO:0050852 TAS:UniProtKBPT cell receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120870Phospholipid metabolism
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_121175PI Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_121025Synthesis of PIPs at the plasma membrane
SMP Pathway Links
SMP IDDescription
SMP00582Joubert syndrome
SMP00463Phosphatidylinositol Phosphate Metabolism
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