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MGP002293

Record overview

MGPD IDMGP002293
Gene ID5294
SpeciesHomo sapiens (Human)
Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Gene Symbol PIK3CG
SynonymsPI3K; PIK3; PI3CG; PI3Kgamma; p110gamma; p120-PI3K;
Alternate namesphosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; 1-phosphatidylinositol 3-kinase; PI3-kinase subunit gamma; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase gamma catalytic subunit; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG;
Chromosome7
Map Location7q22.3
EC Number2.7.1.153
SummaryThis gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for PIK3CG

Proteins

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Refseq ID:NP_002640
Protein GI:21237725
UniProt ID:P48736
mRNA ID:NM_002649
Length:1102
RefSeq Status:
MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLY
QKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHP
WVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG
EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTS
PKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNAD
KLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLR
SEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEK
CKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGK
KTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKH
SA
 
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Refseq ID:NP_001269356
Protein GI:539846764
UniProt ID:P48736
mRNA ID:NM_001282427
Length:1102
RefSeq Status:
Protein sequence is identical to GI:21237725 (mRNA isoform)
 
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Refseq ID:NP_001269355
Protein GI:539846630
UniProt ID:P48736
mRNA ID:NM_001282426
Length:1102
RefSeq Status:
Protein sequence is identical to GI:21237725 (mRNA isoform)
 
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