MGP Database

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MGP002293

Ontology/Pathway Information

Entrez Gene ID5294
Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Gene Symbol PIK3CG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0042629 TAS:GOCCmast cell granule
GO:0016020 IDA:UniProtKBCmembrane
GO:0005944 IDA:UniProtKBCphosphatidylinositol 3-kinase complex, class IB
GO:0005886 IBA:GO_CentralCplasma membrane
GO:0016303 IBA:GO_CentralF1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:GO_CentralF1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046875 IPI:UniProtKBFephrin receptor binding
GO:0035004 TAS:UniProtKBFphosphatidylinositol 3-kinase activity
GO:0046934 IBA:GO_CentralFphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0004672 TAS:UniProtKBFprotein kinase activity
GO:0004674 IEA:UniProtKB-KWFprotein serine/threonine kinase activity
GO:0002250 TAS:UniProtKBPadaptive immune response
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0001816 TAS:UniProtKBPcytokine production
GO:0002407 TAS:UniProtKBPdendritic cell chemotaxis
GO:0006897 IEA:UniProtKB-KWPendocytosis
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0097284 IEA:EnsemblPhepatocyte apoptotic process
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0043303 TAS:UniProtKBPmast cell degranulation
GO:0035747 TAS:UniProtKBPnatural killer cell chemotaxis
GO:0055118 TAS:UniProtKBPnegative regulation of cardiac muscle contraction
GO:2000270 IEA:EnsemblPnegative regulation of fibroblast apoptotic process
GO:0010897 IEA:EnsemblPnegative regulation of triglyceride catabolic process
GO:0030593 TAS:UniProtKBPneutrophil chemotaxis
GO:0072672 TAS:UniProtKBPneutrophil extravasation
GO:0014065 IDA:UniProtKBPphosphatidylinositol 3-kinase signaling
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0030168 TAS:ReactomePplatelet activation
GO:0070527 TAS:UniProtKBPplatelet aggregation
GO:0002675 IEA:EnsemblPpositive regulation of acute inflammatory response
GO:0007204 IEA:EnsemblPpositive regulation of cytosolic calcium ion concentration
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0051897 IDA:UniProtKBPpositive regulation of protein kinase B signaling
GO:0033628 TAS:UniProtKBPregulation of cell adhesion mediated by integrin
GO:0002679 TAS:UniProtKBPrespiratory burst involved in defense response
GO:0032252 IEA:EnsemblPsecretory granule localization
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042110 TAS:UniProtKBPT cell activation
GO:0010818 TAS:UniProtKBPT cell chemotaxis
GO:0042098 TAS:UniProtKBPT cell proliferation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_120870Phospholipid metabolism
REACT_121175PI Metabolism
REACT_798Platelet activation, signaling and aggregation
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_121025Synthesis of PIPs at the plasma membrane
SMP Pathway Links
SMP IDDescription
SMP00391Insulin Signalling
SMP00682Leucine Stimulation on Insulin Signaling
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