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MGP002309

Record overview

MGPD IDMGP002309
Gene ID5322
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group V
Gene Symbol PLA2G5
SynonymsFRFB; GV-PLA2; PLA2-10; hVPLA(2);
Alternate namescalcium-dependent phospholipase A2; Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5;
Chromosome1
Map Location1p36-p34
EC Number3.1.1.4
SummaryThis gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PLA2G5

Proteins

calcium-dependent phospholipase A2 precursor
Refseq ID:NP_000920
Protein GI:4505853
UniProt ID:P39877
mRNA ID:NM_000929
Length:138
RefSeq Status:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPG
PFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2102
peptide sequence: 
MKGLLPLAWFLACSVPAVQG

mat_peptide: 21..138
product: calcium-dependent phospholipase A2
calculated_mol_wt: 13591
peptide sequence: 
GLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKR
NLRSYNPQYQYFPNILCS
 
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