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MGP002309

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group V
Protein EntryPA2G5_HUMAN
UniProt IDP39877
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0.;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
DiseaseFleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269|PubMed:22137173}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
PtmThis enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityHeart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level). {ECO:0000269|PubMed:22137173}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g5/";
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