MGP Database

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MGP002329

Ontology/Pathway Information

Entrez Gene ID5350
Gene Namephospholamban
Gene Symbol PLN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0090534 IDA:BHF-UCLCcalcium ion-transporting ATPase complex
GO:0005783 ISS:BHF-UCLCendoplasmic reticulum
GO:0016020 IDA:BHF-UCLCmembrane
GO:0031966 IEA:UniProtKB-SubCellCmitochondrial membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0048471 ISS:BHF-UCLCperinuclear region of cytoplasm
GO:0033017 IEA:UniProtKB-SubCellCsarcoplasmic reticulum membrane
GO:0031982 IEA:EnsemblCvesicle
GO:0051117 ISS:BHF-UCLFATPase binding
GO:0042030 IDA:BHF-UCLFATPase inhibitor activity
GO:0005246 IEA:InterProFcalcium channel regulator activity
GO:0004857 ISS:BHF-UCLFenzyme inhibitor activity
GO:0042802 ISS:BHF-UCLFidentical protein binding
GO:0086023 IEA:EnsemblPadrenergic receptor signaling pathway involved in heart process
GO:0008015 NAS:ProtIncPblood circulation
GO:0006816 IEA:InterProPcalcium ion transport
GO:0048738 IEA:EnsemblPcardiac muscle tissue development
GO:0051480 IC:BHF-UCLPcytosolic calcium ion homeostasis
GO:0032780 IDA:BHF-UCLPnegative regulation of ATPase activity
GO:1901877 IDA:BHF-UCLPnegative regulation of calcium ion binding
GO:0090281 ISS:BHF-UCLPnegative regulation of calcium ion import
GO:1902081 ISS:BHF-UCLPnegative regulation of calcium ion import into sarcoplasmic reticulum
GO:1901020 IDA:BHF-UCLPnegative regulation of calcium ion transmembrane transporter activity
GO:0051926 IDA:BHF-UCLPnegative regulation of calcium ion transport
GO:1901895 IDA:BHF-UCLPnegative regulation of calcium-transporting ATPase activity
GO:0043086 ISS:BHF-UCLPnegative regulation of catalytic activity
GO:0010459 IMP:BHF-UCLPnegative regulation of heart rate
GO:0051260 IEA:EnsemblPprotein homooligomerization
GO:0051924 IDA:UniProtKBPregulation of calcium ion transport
GO:1901894 IDA:UniProtKBPregulation of calcium-transporting ATPase activity
GO:0086004 IC:BHF-UCLPregulation of cardiac muscle cell contraction
GO:0086036 IC:BHF-UCLPregulation of cardiac muscle cell membrane potential
GO:0010881 IEA:EnsemblPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0008016 IMP:BHF-UCLPregulation of heart contraction
GO:1901897 IC:BHF-UCLPregulation of relaxation of cardiac muscle
GO:0060314 IEA:EnsemblPregulation of ryanodine-sensitive calcium-release channel activity
GO:0002026 IC:BHF-UCLPregulation of the force of heart contraction
GO:0086092 IEA:EnsemblPregulation of the force of heart contraction by cardiac conduction
GO:0055119 TAS:BHF-UCLPrelaxation of cardiac muscle
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0010043 IEA:EnsemblPresponse to zinc ion
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25300Ion channel transport
REACT_25149Ion transport by P-type ATPases
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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