MGP Database

MGP002337

Ontology/Pathway Information

Entrez Gene ID	5366
Gene Name	phorbol-12-myristate-13-acetate-induced protein 1
Gene Symbol	PMAIP1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0005741	TAS:Reactome	C	mitochondrial outer membrane
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915	IMP:MGI	P	apoptotic process
GO:0042149	IMP:UniProtKB	P	cellular response to glucose starvation
GO:0071456	IEP:UniProtKB	P	cellular response to hypoxia
GO:0051607	IDA:BHF-UCL	P	defense response to virus
GO:0097193	IDA:UniProtKB	P	intrinsic apoptotic signaling pathway
GO:0072332	IMP:UniProtKB	P	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0048147	IEA:Ensembl	P	negative regulation of fibroblast proliferation
GO:0010917	ISS:UniProtKB	P	negative regulation of mitochondrial membrane potential
GO:0043065	IDA:UniProtKB	P	positive regulation of apoptotic process
GO:0043280	IDA:UniProtKB	P	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043517	IMP:UniProtKB	P	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902043	IDA:BHF-UCL	P	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0010907	IDA:UniProtKB	P	positive regulation of glucose metabolic process
GO:2001244	IDA:UniProtKB	P	positive regulation of intrinsic apoptotic signaling pathway
GO:0043525	IEA:Ensembl	P	positive regulation of neuron apoptotic process
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461	IDA:UniProtKB	P	positive regulation of protein oligomerization
GO:0090200	IDA:UniProtKB	P	positive regulation of release of cytochrome c from mitochondria
GO:0010498	IDA:UniProtKB	P	proteasomal protein catabolic process
GO:0072593	IDA:UniProtKB	P	reactive oxygen species metabolic process
GO:0046902	IDA:UniProtKB	P	regulation of mitochondrial membrane permeability
GO:0001836	IEA:Ensembl	P	release of cytochrome c from mitochondria
GO:0043331	IDA:HGNC	P	response to dsRNA
GO:0009411	IEA:Ensembl	P	response to UV
GO:0010165	IEA:Ensembl	P	response to X-ray
GO:0043029	ISS:UniProtKB	P	T cell homeostasis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_697	Activation of BH3-only proteins
REACT_1194	Activation of NOXA and translocation to mitochondria
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_964	Intrinsic Pathway for Apoptosis
REACT_268456	Programmed Cell Death