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MGP002337

UniProt Annotations

Entry Information
Gene Namephorbol-12-myristate-13-acetate-induced protein 1
Protein EntryAPR_HUMAN
UniProt IDQ13794
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13794-1; Sequence=Displayed; Name=2; IsoId=Q13794-2; Sequence=VSP_056247; Note=No experimental confirmation available.;
DomainThe BH3 motif is essential for pro-apoptotic activity.
FunctionPromotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
InductionUp-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. {ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
InteractionP10415:BCL2; NbExp=3; IntAct=EBI-707392, EBI-77694; P10415-1:BCL2; NbExp=3; IntAct=EBI-707392, EBI-4370304; Q07820:MCL1; NbExp=5; IntAct=EBI-707392, EBI-1003422;
SimilarityBelongs to the PMAIP1 family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
SubunitInteracts with MCL1, BCL2A1 and BAX. {ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404, ECO:0000269|Ref.10}.
Tissue SpecificityHighly expressed in adult T-cell leukemia cell line.
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