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MGP002341

UniProt Annotations

Entry Information
Gene Namephosphomannomutase 1
Protein EntryPMM1_HUMAN
UniProt IDQ92871
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=54 uM for alpha-D-mannose 1-phosphate {ECO:0000269|PubMed:16540464}; KM=7.5 uM for alpha-D-glucose 1-phosphate {ECO:0000269|PubMed:16540464};
Catalytic ActivityAlpha-D-mannose 1-phosphate = D-mannose 6- phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16540464};
Enzyme RegulationIMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6- bisphosphatase activity. {ECO:0000250}.
FunctionInvolved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.
PathwayNucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6- phosphate: step 2/2.
SimilarityBelongs to the eukaryotic PMM family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:16540464}.
Tissue SpecificityStrong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
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