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MGP002354

UniProt Annotations

Entry Information
Gene Namepolymerase (DNA directed), epsilon 2, accessory subunit
Protein EntryDPOE2_HUMAN
UniProt IDP56282
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56282-1; Sequence=Displayed; Name=2; IsoId=P56282-2; Sequence=VSP_042551; Note=No experimental confirmation available.; Name=3; IsoId=P56282-3; Sequence=VSP_043796;
Catalytic ActivityDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
FunctionParticipates in DNA repair and in chromosomal DNA replication.
MiscellaneousIn eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
SimilarityBelongs to the DNA polymerase epsilon subunit B family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitComponent of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. {ECO:0000269|PubMed:10801849}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pole2/";
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