MGP Database

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MGP002364

UniProt Annotations

Entry Information
Gene Namepolymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
Protein EntryRPB9_HUMAN
UniProt IDP36954
SpeciesHuman
Comments
Comment typeDescription
FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). {ECO:0000250}.
SimilarityBelongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. {ECO:0000305}.
SimilarityContains 1 TFIIS-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00472}.
Subcellular LocationNucleus {ECO:0000269|PubMed:9852112}.
SubunitComponent of the RNA polymerase II (Pol II) complex consisting of 12 subunits. {ECO:0000269|PubMed:9852112}.
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