MGP Database

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MGP002367

UniProt Annotations

Entry Information
Gene Namepolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Protein EntryRPAB5_HUMAN
UniProt IDP62875
SpeciesHuman
Comments
Comment typeDescription
FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.
SimilarityBelongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}.
SubunitComponent of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. {ECO:0000250}.
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