MGP Database

MGP002369

Record overview

MGPD IDMGP002369
Gene ID5443
SpeciesHomo sapiens (Human)
Gene Nameproopiomelanocortin
Gene Symbol POMC
SynonymsLPH; MSH; NPP; POC; ACTH; CLIP;
Alternate namespro-opiomelanocortin; adrenocorticotropic hormone; adrenocorticotropin; alpha-MSH; alpha-melanocyte-stimulating hormone; beta-LPH; beta-MSH; beta-endorphin; beta-melanocyte-stimulating hormone; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-LPH; gamma-MSH; lipotropin beta; lipotropin gamma; melanotropin alpha; melanotropin beta; melanotropin gamma; met-enkephalin; opiomelanocortin prepropeptide; pro-ACTH-endorphin; proopiomelanocortin preproprotein;
Chromosome2
Map Location2p23.3
SummaryThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]
OrthologsView orthologs and multiple alignments for POMC

Proteins

pro-opiomelanocortin preproprotein
Refseq ID:NP_000930
Protein GI:4505949
UniProt ID:P01189
mRNA ID:NM_000939
Length:267
RefSeq Status:
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGA
GQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAG
AQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2763
peptide sequence: 
MPRSCCSRSGALLLALLLQASMEVRG

mat_peptide: 27..102
product: N-terminal peptide
calculated_mol_wt: 8469
peptide sequence: 
WCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQ

mat_peptide: 77..87
product: melanotropin gamma
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1514
peptide sequence: 
YVMGHFRWDRF

mat_peptide: 105..134
product: joining peptide
calculated_mol_wt: 3006
peptide sequence: 
EDVSAGEDCGPLPEGGPEPRSDGAKPGPRE

mat_peptide: 138..176
product: adrenocorticotropin
calculated_mol_wt: 4541
peptide sequence: 
SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF

mat_peptide: 138..150
product: melanotropin alpha
experiment: DESCRIPTION:antimicrobial peptide[PMID: 25140322]
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1624
peptide sequence: 
SYSMEHFRWGKPV

mat_peptide: 156..176
product: corticotropin-like intermediary peptide
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2310
peptide sequence: 
PVKVYPNGAEDESAEAFPLEF

mat_peptide: 179..267
product: lipotropin beta
calculated_mol_wt: 9806
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 179..234
product: lipotropin gamma
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 6075
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKD

mat_peptide: 217..234
product: melanotropin beta
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2204
peptide sequence: 
DEGPYRMEHFRWGSPPKD

mat_peptide: 237..267
product: beta-endorphin
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 3465
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 237..263
product: beta-endorphin (1-27)
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 3023
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAY

mat_peptide: 237..241
product: met-enkephalin
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 574
peptide sequence: 
YGGFM
 
pro-opiomelanocortin preproprotein
Refseq ID:NP_001030333
Protein GI:80861463
UniProt ID:P01189
mRNA ID:NM_001035256
Length:267
RefSeq Status:
Protein sequence is identical to GI:4505949 (mRNA isoform)
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2763
peptide sequence: 
MPRSCCSRSGALLLALLLQASMEVRG

mat_peptide: 27..102
product: N-terminal peptide
calculated_mol_wt: 8469
peptide sequence: 
WCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQ

mat_peptide: 77..87
product: melanotropin gamma
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1514
peptide sequence: 
YVMGHFRWDRF

mat_peptide: 105..134
product: joining peptide
calculated_mol_wt: 3006
peptide sequence: 
EDVSAGEDCGPLPEGGPEPRSDGAKPGPRE

mat_peptide: 138..176
product: adrenocorticotropin
calculated_mol_wt: 4541
peptide sequence: 
SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF

mat_peptide: 138..150
product: melanotropin alpha
experiment: DESCRIPTION:antimicrobial peptide[PMID: 25140322]
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1624
peptide sequence: 
SYSMEHFRWGKPV

mat_peptide: 156..176
product: corticotropin-like intermediary peptide
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2310
peptide sequence: 
PVKVYPNGAEDESAEAFPLEF

mat_peptide: 179..267
product: lipotropin beta
calculated_mol_wt: 9806
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 179..234
product: lipotropin gamma
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 6075
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKD

mat_peptide: 217..234
product: melanotropin beta
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2204
peptide sequence: 
DEGPYRMEHFRWGSPPKD

mat_peptide: 237..267
product: beta-endorphin
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 3465
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 237..263
product: beta-endorphin (1-27)
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 3023
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAY

mat_peptide: 237..241
product: met-enkephalin
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 574
peptide sequence: 
YGGFM

sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2763
peptide sequence: 
MPRSCCSRSGALLLALLLQASMEVRG

mat_peptide: 27..102
product: N-terminal peptide
calculated_mol_wt: 8469
peptide sequence: 
WCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQ

mat_peptide: 77..87
product: melanotropin gamma
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1514
peptide sequence: 
YVMGHFRWDRF

mat_peptide: 105..134
product: joining peptide
calculated_mol_wt: 3006
peptide sequence: 
EDVSAGEDCGPLPEGGPEPRSDGAKPGPRE

mat_peptide: 138..176
product: adrenocorticotropin
calculated_mol_wt: 4541
peptide sequence: 
SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF

mat_peptide: 138..150
product: melanotropin alpha
experiment: DESCRIPTION:antimicrobial peptide[PMID: 25140322]
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 1624
peptide sequence: 
SYSMEHFRWGKPV

mat_peptide: 156..176
product: corticotropin-like intermediary peptide
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2310
peptide sequence: 
PVKVYPNGAEDESAEAFPLEF

mat_peptide: 179..267
product: lipotropin beta
calculated_mol_wt: 9806
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 179..234
product: lipotropin gamma
exception: alternative processing
calculated_mol_wt: 6075
peptide sequence: 
ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKD

mat_peptide: 217..234
product: melanotropin beta
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 2204
peptide sequence: 
DEGPYRMEHFRWGSPPKD

mat_peptide: 237..267
product: beta-endorphin
exception: alternative processing
calculated_mol_wt: 3465
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

mat_peptide: 237..263
product: beta-endorphin (1-27)
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 3023
peptide sequence: 
YGGFMTSEKSQTPLVTLFKNAIIKNAY

mat_peptide: 237..241
product: met-enkephalin
exception: alternative processing
note: occurs in cells other than corticotroph cells of the anterior pituitary
calculated_mol_wt: 574
peptide sequence: 
YGGFM
 
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