MGP Database

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MGP002369

Ontology/Pathway Information

Entrez Gene ID5443
Gene Nameproopiomelanocortin
Gene Symbol POMC
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005782 IDA:UniProtKBCperoxisomal matrix
GO:0030141 ISS:UniProtKBCsecretory granule
GO:0034774 TAS:ReactomeCsecretory granule lumen
GO:0001664 IDA:BHF-UCLFG-protein coupled receptor binding
GO:0005179 IMP:UniProtKBFhormone activity
GO:0005102 IMP:UniProtKBFreceptor binding
GO:0070996 IDA:BHF-UCLFtype 1 melanocortin receptor binding
GO:0031781 IPI:BHF-UCLFtype 3 melanocortin receptor binding
GO:0031782 IPI:BHF-UCLFtype 4 melanocortin receptor binding
GO:0007267 IMP:UniProtKBPcell-cell signaling
GO:0033059 IMP:UniProtKBPcellular pigmentation
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0006091 IMP:UniProtKBPgeneration of precursor metabolites and energy
GO:0042593 IEA:EnsemblPglucose homeostasis
GO:0032720 IDA:BHF-UCLPnegative regulation of tumor necrosis factor production
GO:0007218 IEA:UniProtKB-KWPneuropeptide signaling pathway
GO:0016486 TAS:ReactomePpeptide hormone processing
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0032098 IMP:UniProtKBPregulation of appetite
GO:0008217 ISS:UniProtKBPregulation of blood pressure
GO:2000852 IEA:EnsemblPregulation of corticosterone secretion
GO:0070873 IEA:EnsemblPregulation of glycogen metabolic process
GO:0007165 IMP:UniProtKBPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11059Androgen biosynthesis
REACT_13433Biological oxidations
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_19231G alpha (i) signalling events
REACT_19327G alpha (s) signalling events
REACT_11036Glucocorticoid biosynthesis
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_15457G-protein activation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_17015Metabolism of proteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_15295Opioid Signalling
REACT_15452Peptide hormone biosynthesis
REACT_160078Peptide hormone metabolism
REACT_14819Peptide ligand-binding receptors
REACT_13705Phase 1 - Functionalization of compounds
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00310Corticotropin Activation of Cortisol Production
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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