MGP Database

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MGP002374

UniProt Annotations

Entry Information
Gene Namepyrophosphatase (inorganic) 1
Protein EntryIPYR_HUMAN
UniProt IDQ15181
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityDiphosphate + H(2)O = 2 phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg(2+) ions form complexes with substrate and product. {ECO:0000250};
SimilarityBelongs to the PPase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityExpressed ubiquitously. {ECO:0000269|PubMed:10542310}.
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