MGP Database

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MGP002378

Ontology/Pathway Information

Entrez Gene ID5469
Gene Namemediator complex subunit 1
Gene Symbol MED1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000785 IEA:EnsemblCchromatin
GO:0016592 IDA:UniProtKBCmediator complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0032993 IEA:EnsemblCprotein-DNA complex
GO:0003682 IMP:UniProtKBFchromatin binding
GO:0031490 IEA:EnsemblFchromatin DNA binding
GO:0001047 IDA:UniProtKBFcore promoter binding
GO:0030331 IPI:UniProtKBFestrogen receptor binding
GO:0050693 IPI:UniProtKBFLBD domain binding
GO:0016922 IDA:UniProtKBFligand-dependent nuclear receptor binding
GO:0030374 IMP:UniProtKBFligand-dependent nuclear receptor transcription coactivator activity
GO:0036033 IDA:UniProtKBFmediator complex binding
GO:0035257 IPI:UniProtKBFnuclear hormone receptor binding
GO:0042975 IPI:UniProtKBFperoxisome proliferator activated receptor binding
GO:0004872 IDA:UniProtKBFreceptor activity
GO:0042974 IPI:UniProtKBFretinoic acid receptor binding
GO:0000978 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001104 IDA:UniProtKBFRNA polymerase II transcription cofactor activity
GO:0000981 ISS:UniProtKBFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046966 IDA:UniProtKBFthyroid hormone receptor binding
GO:0030375 IMP:UniProtKBFthyroid hormone receptor coactivator activity
GO:0003713 IDA:UniProtKBFtranscription coactivator activity
GO:0003712 IDA:UniProtKBFtranscription cofactor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0042809 IPI:UniProtKBFvitamin D receptor binding
GO:0006702 IMP:UniProtKBPandrogen biosynthetic process
GO:0030521 IDA:UniProtKBPandrogen receptor signaling pathway
GO:0001525 ISS:UniProtKBPangiogenesis
GO:0007420 IEA:EnsemblPbrain development
GO:0000902 IMP:UniProtKBPcell morphogenesis
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0071364 IDA:UniProtKBPcellular response to epidermal growth factor stimulus
GO:0035729 IEA:EnsemblPcellular response to hepatocyte growth factor stimulus
GO:0071383 IDA:UniProtKBPcellular response to steroid hormone stimulus
GO:0097067 IDA:UniProtKBPcellular response to thyroid hormone stimulus
GO:0035050 IEA:EnsemblPembryonic heart tube development
GO:0035162 IEA:EnsemblPembryonic hemopoiesis
GO:0035116 IEA:EnsemblPembryonic hindlimb morphogenesis
GO:0001892 IEA:EnsemblPembryonic placenta development
GO:0048822 IEA:EnsemblPenucleate erythrocyte development
GO:0060750 IEA:EnsemblPepithelial cell proliferation involved in mammary gland duct elongation
GO:0070371 IDA:UniProtKBPERK1 and ERK2 cascade
GO:0048821 ISS:UniProtKBPerythrocyte development
GO:0045444 IDA:MGIPfat cell differentiation
GO:0010467 TAS:ReactomePgene expression
GO:0030518 IDA:UniProtKBPintracellular steroid hormone receptor signaling pathway
GO:0030216 IMP:UniProtKBPkeratinocyte differentiation
GO:0007595 IEA:EnsemblPlactation
GO:0002088 ISS:UniProtKBPlens development in camera-type eye
GO:0001889 IEA:EnsemblPliver development
GO:0060745 IEA:EnsemblPmammary gland branching involved in pregnancy
GO:0060744 IEA:EnsemblPmammary gland branching involved in thelarche
GO:0035855 ISS:UniProtKBPmegakaryocyte development
GO:0030224 IEA:EnsemblPmonocyte differentiation
GO:0042789 ISS:UniProtKBPmRNA transcription from RNA polymerase II promoter
GO:0043066 ISS:UniProtKBPnegative regulation of apoptotic process
GO:0010839 IMP:UniProtKBPnegative regulation of keratinocyte proliferation
GO:0045665 ISS:UniProtKBPnegative regulation of neuron differentiation
GO:0000122 ISS:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0035357 IEA:EnsemblPperoxisome proliferator activated receptor signaling pathway
GO:0070318 IEA:EnsemblPpositive regulation of G0 to G1 transition
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:2000347 IEA:EnsemblPpositive regulation of hepatocyte proliferation
GO:0060335 IEA:EnsemblPpositive regulation of interferon-gamma-mediated signaling pathway
GO:0033148 IEA:EnsemblPpositive regulation of intracellular estrogen receptor signaling pathway
GO:0045618 IMP:UniProtKBPpositive regulation of keratinocyte differentiation
GO:0033601 IEA:EnsemblPpositive regulation of mammary gland epithelial cell proliferation
GO:0033160 IEA:EnsemblPpositive regulation of protein import into nucleus, translocation
GO:2000273 IMP:UniProtKBPpositive regulation of receptor activity
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0051726 NAS:UniProtKBPregulation of cell cycle
GO:2001141 IMP:UniProtKBPregulation of RNA biosynthetic process
GO:0006356 IDA:UniProtKBPregulation of transcription from RNA polymerase I promoter
GO:0070562 IEA:EnsemblPregulation of vitamin D receptor signaling pathway
GO:0003406 IEA:EnsemblPretinal pigment epithelium development
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006590 IEA:EnsemblPthyroid hormone generation
GO:0002154 IMP:UniProtKBPthyroid hormone mediated signaling pathway
GO:0006367 IDA:UniProtKBPtranscription initiation from RNA polymerase II promoter
GO:0003222 IEA:EnsemblPventricular trabecula myocardium morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_24941Circadian Clock
REACT_111045Developmental Biology
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_264351Mitochondrial biogenesis
REACT_15525Nuclear Receptor transcription pathway
REACT_264135Organelle biogenesis and maintenance
REACT_268444Orphan transporters
REACT_116145PPARA activates gene expression
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_118789REV-ERBA represses gene expression
REACT_118659RORA activates circadian gene expression
REACT_264212Transcriptional activation of mitochondrial biogenesis
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_15518Transmembrane transport of small molecules
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
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