MGP Database

MGP002379

Ontology/Pathway Information

Entrez Gene ID	5471
Gene Name	phosphoribosyl pyrophosphate amidotransferase
Gene Symbol	PPAT
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0051539	IEA:UniProtKB-KW	F	4 iron, 4 sulfur cluster binding
GO:0004044	TAS:ProtInc	F	amidophosphoribosyltransferase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0006189	IEA:UniProtKB-UniPathway	P	'de novo' IMP biosynthetic process
GO:0000082	IEA:Ensembl	P	G1/S transition of mitotic cell cycle
GO:0006543	IEA:Ensembl	P	glutamine catabolic process
GO:0001822	IEA:Ensembl	P	kidney development
GO:0007595	IEA:Ensembl	P	lactation
GO:0060135	IEA:Ensembl	P	maternal process involved in female pregnancy
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0009116	IEA:InterPro	P	nucleoside metabolic process
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0051289	IEA:Ensembl	P	protein homotetramerization
GO:0009113	IEA:InterPro	P	purine nucleobase biosynthetic process
GO:0006144	TAS:Reactome	P	purine nucleobase metabolic process
GO:0006164	TAS:ProtInc	P	purine nucleotide biosynthetic process
GO:0009168	TAS:Reactome	P	purine ribonucleoside monophosphate biosynthetic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_522	Purine metabolism
REACT_1776	Purine ribonucleoside monophosphate biosynthesis

SMP Pathway Links

SMP ID	Description
SMP00136	2-Hydroxyglutric Aciduria (D And L Form)
SMP00243	4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
SMP00535	Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144	Adenosine Deaminase Deficiency
SMP00167	Adenylosuccinate Lyase Deficiency
SMP00168	AICA-Ribosiduria
SMP00427	Azathioprine Action Pathway
SMP00072	Glutamate Metabolism
SMP00365	Gout or Kelley-Seegmiller Syndrome
SMP00385	Homocarnosinosis
SMP00339	Hyperinsulinism-Hyperammonemia Syndrome
SMP00364	Lesch-Nyhan Syndrome (LNS)
SMP00428	Mercaptopurine Action Pathway
SMP00609	Mercaptopurine Metabolism Pathway
SMP00536	Mitochondrial DNA depletion syndrome
SMP00203	Molybdenum Cofactor Deficiency
SMP00537	Myoadenylate deaminase deficiency
SMP00050	Purine Metabolism
SMP00210	Purine Nucleoside Phosphorylase Deficiency
SMP00567	Succinic semialdehyde dehydrogenase deficiency
SMP00430	Thioguanine Action Pathway
SMP00220	Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512	Xanthinuria type I
SMP00513	Xanthinuria type II