MGP Database

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MGP002379

UniProt Annotations

Entry Information
Gene Namephosphoribosyl pyrophosphate amidotransferase
Protein EntryPUR1_HUMAN
UniProt IDQ06203
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000250};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate: step 1/2.
SimilarityContains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule:PRU00609}.
SimilarityIn the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. {ECO:0000305}.
SubunitHomotetramer.
Tissue SpecificityUbiquitously expressed.
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