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MGP002380

Record overview

MGPD IDMGP002380
Gene ID5473
SpeciesHomo sapiens (Human)
Gene Namepro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Gene Symbol PPBP
SynonymsPBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III;
Alternate namesplatelet basic protein; C-X-C motif chemokine 7; CXC chemokine ligand 7; beta-thromboglobulin; connective tissue-activating peptide III; leukocyte-derived growth factor; low-affinity platelet factor IV; macrophage-derived growth factor; neutrophil-activating peptide 2; neutrophil-activating peptide-2; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; small-inducible cytokine B7; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1;
Chromosome4
Map Location4q12-q13
SummaryThe protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
OrthologsView orthologs and multiple alignments for PPBP

Proteins

platelet basic protein preproprotein
Refseq ID:NP_002695
Protein GI:4505981
UniProt ID:P02775
mRNA ID:NM_002704
Length:128
RefSeq Status:
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKD
GRKICLDPDAPRIKKIVQKKLAGDESAD
 
sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3646
peptide sequence: 
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALA

mat_peptide: 44..128
product: LA-PF4/CTAP-III
calculated_mol_wt: 9292
peptide sequence: 
NLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

mat_peptide: 44..128
product: thrombocidin-2
experiment: DESCRIPTION:antimicrobial peptide[PMID: 10877842]
calculated_mol_wt: 9292
peptide sequence: 
NLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

mat_peptide: 48..128
product: beta-thromboglobulin
calculated_mol_wt: 8865
peptide sequence: 
GKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

mat_peptide: 59..126
product: thrombocidin-1
experiment: DESCRIPTION:antimicrobial peptide[PMID: 10877842]
calculated_mol_wt: 7442
peptide sequence: 
AELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES
 
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