MGP Database

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MGP002385

Ontology/Pathway Information

Entrez Gene ID5494
Gene Nameprotein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Symbol PPM1A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 ISS:UniProtKBCcytosol
GO:0016020 ISS:UniProtKBCmembrane
GO:0043005 IEA:EnsemblCneuron projection
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005891 IEA:EnsemblCvoltage-gated calcium channel complex
GO:0033192 IDA:UniProtKBFcalmodulin-dependent protein phosphatase activity
GO:0000287 IEA:InterProFmagnesium ion binding
GO:0030145 IEA:InterProFmanganese ion binding
GO:0004722 IDA:UniProtKBFprotein serine/threonine phosphatase activity
GO:0070412 IPI:UniProtKBFR-SMAD binding
GO:0004871 IMP:UniProtKBFsignal transducer activity
GO:0007050 TAS:ReactomePcell cycle arrest
GO:0016311 IDA:BHF-UCLPdephosphorylation
GO:0010467 TAS:ReactomePgene expression
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0043124 IMP:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042347 IMP:UniProtKBPnegative regulation of NF-kappaB import into nucleus
GO:0010991 IDA:UniProtKBPnegative regulation of SMAD protein complex assembly
GO:0000122 TAS:ReactomePnegative regulation of transcription from RNA polymerase II promoter
GO:0030512 IDA:UniProtKBPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0006499 ISS:UniProtKBPN-terminal protein myristoylation
GO:0035970 IDA:UniProtKBPpeptidyl-threonine dephosphorylation
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0030177 IDA:BHF-UCLPpositive regulation of Wnt signaling pathway
GO:0006470 IMP:UniProtKBPprotein dephosphorylation
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0016055 IDA:BHF-UCLPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_150210IGF1R signaling cascade
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6838mTOR signalling
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_21285Regulation of AMPK activity via LKB1
REACT_498Signaling by Insulin receptor
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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