MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002385

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase, Mg2+/Mn2+ dependent, 1A
Protein EntryPPM1A_HUMAN
UniProt IDP35813
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Alpha-1; IsoId=P35813-1; Sequence=Displayed; Name=Alpha-2; IsoId=P35813-2; Sequence=VSP_005085, VSP_005086; Name=3; IsoId=P35813-3; Sequence=VSP_045687; Note=No experimental confirmation available. Ref.3 (AK097843) sequence is in conflict in position: 54:Q->R. {ECO:0000305};
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
FunctionEnzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
InteractionP49407:ARRB1; NbExp=4; IntAct=EBI-989143, EBI-743313; P32121:ARRB2; NbExp=3; IntAct=EBI-989143, EBI-714559; O15169:AXIN1; NbExp=2; IntAct=EBI-989143, EBI-710484; P28482:MAPK1; NbExp=19; IntAct=EBI-989143, EBI-959949; Q16539:MAPK14; NbExp=2; IntAct=EBI-989143, EBI-73946; Q9H6Z4:RANBP3; NbExp=4; IntAct=EBI-989143, EBI-992681; Q15796:SMAD2; NbExp=2; IntAct=EBI-989143, EBI-1040141;
PtmN-myristoylation is essential for the recognition of its substrates for dephosphorylation. {ECO:0000250}.
SimilarityBelongs to the PP2C family. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.
SubunitMonomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
  logo