MGP Database

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MGP002399

Ontology/Pathway Information

Entrez Gene ID5527
Gene Nameprotein phosphatase 2, regulatory subunit B', gamma
Gene Symbol PPP2R5C
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000775 IDA:UniProtKBCchromosome, centromeric region
GO:0005634 IDA:UniProtKBCnucleus
GO:0000159 IDA:UniProtKBCprotein phosphatase type 2A complex
GO:0008601 IDA:UniProtKBFprotein phosphatase type 2A regulator activity
GO:0006977 IDA:UniProtKBPDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0042771 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0043161 IMP:MGIPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790 IDA:GOCPregulation of catalytic activity
GO:0007165 NAS:UniProtKBPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_11065Beta-catenin phosphorylation cascade
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_604Hemostasis
REACT_6900Immune System
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_1275Mitotic Anaphase
REACT_150314Mitotic Metaphase and Anaphase
REACT_682Mitotic Prometaphase
REACT_910M Phase
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_23876Platelet homeostasis
REACT_23879Platelet sensitization by LDL
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_150471Separation of Sister Chromatids
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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