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MGP002401

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 2, regulatory subunit B', epsilon isoform
Protein Entry2A5E_HUMAN
UniProt IDQ16537
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16537-1; Sequence=Displayed; Name=2; IsoId=Q16537-2; Sequence=VSP_054588; Note=No experimental confirmation available.; Name=3; IsoId=Q16537-3; Sequence=VSP_055163; Note=No experimental confirmation available.;
FunctionThe B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
InteractionO96017:CHEK2; NbExp=3; IntAct=EBI-968374, EBI-1180783; Q86YF9:DZIP1; NbExp=3; IntAct=EBI-968374, EBI-998108; P30153:PPP2R1A; NbExp=3; IntAct=EBI-968374, EBI-302388; P30154:PPP2R1B; NbExp=3; IntAct=EBI-968374, EBI-357094; Q9H0H5:RACGAP1; NbExp=5; IntAct=EBI-968374, EBI-717233; Q8IUH5:ZDHHC17; NbExp=2; IntAct=EBI-968374, EBI-524753;
PtmPhosphorylated on serine residues. {ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the phosphatase 2A regulatory subunit B56 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitFound in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. {ECO:0000250, ECO:0000269|PubMed:16541025}.
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