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MGP002402

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 3, catalytic subunit, alpha isozyme
Protein EntryPP2BA_HUMAN
UniProt IDQ08209
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q08209-1; Sequence=Displayed; Name=2; IsoId=Q08209-2; Sequence=VSP_018562; Name=3; IsoId=Q08209-3; Sequence=VSP_043378, VSP_018562; Name=4; IsoId=Q08209-4; Sequence=VSP_047755; Name=5; IsoId=Q08209-5; Sequence=VSP_054467;
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Fe(3+); Xref=ChEBI:CHEBI:29034; Note=Binds 1 Fe(3+) ion per subunit.;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
FunctionCalcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:18838687}.
InteractionQ8VHW5:Cacng8 (xeno); NbExp=2; IntAct=EBI-352922, EBI-9086576; P62993:GRB2; NbExp=3; IntAct=EBI-352922, EBI-401755; P63098:PPP3R1; NbExp=2; IntAct=EBI-352922, EBI-915984; P54578:USP14; NbExp=3; IntAct=EBI-352922, EBI-1048016;
SimilarityBelongs to the PPP phosphatase family. PP-2B subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.
SubunitInteracts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity). {ECO:0000250}.
Web ResourceName=Wikipedia; Note=Calcineurin entry; URL="http://en.wikipedia.org/wiki/Calcineurin";
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