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MGP002414

Record overview

MGPD IDMGP002414
Gene ID5566
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase, cAMP-dependent, catalytic, alpha
Gene Symbol PRKACA
SynonymsPKACA; PPNAD4;
Alternate namescAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; protein kinase A catalytic subunit;
Chromosome19
Map Location19p13.1
EC Number2.7.11.11;
SummaryThis gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
OrthologsView orthologs and multiple alignments for PRKACA

Proteins

cAMP-dependent protein kinase catalytic subunit alpha isoform 3
Refseq ID:NP_001291278
Protein GI:748585205
UniProt ID:
mRNA ID:NM_001304349
Length:427
RefSeq Status:
MFTLGYHGAEEWASGETSLEPALEQCPCDCHGEEQGQLGAKVTAEPPKGTCYPSPRGLHPRPGLPREGARGTAKSQGYKYLGWRRPWPWNVVKEFLAKAK
EDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV
PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWA
LGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD
TSNFDDYEEEEIRVSINEKCGKEFSEF
 
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1
Refseq ID:NP_002721
Protein GI:4506055
UniProt ID:P17612
mRNA ID:NM_002730
Length:351
RefSeq Status:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN
FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC
GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
 
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha2
Refseq ID:NP_997401
Protein GI:46909584
UniProt ID:P17612
mRNA ID:NM_207518
Length:343
RefSeq Status:
MASNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE
FSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP
EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ
RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
 
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