MGP Database

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MGP002414

Ontology/Pathway Information

Entrez Gene ID5566
Gene Nameprotein kinase, cAMP-dependent, catalytic, alpha
Gene Symbol PRKACA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031588 IDA:BHF-UCLCAMP-activated protein kinase complex
GO:0034704 TAS:BHF-UCLCcalcium channel complex
GO:0005952 NAS:UniProtKBCcAMP-dependent protein kinase complex
GO:0005813 IDA:UniProtKBCcentrosome
GO:0097546 IEA:EnsemblCciliary base
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:UniProtKB-SubCellCmitochondrion
GO:0031514 IEA:UniProtKB-KWCmotile cilium
GO:0031594 IEA:EnsemblCneuromuscular junction
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IEA:UniProtKB-SubCellCplasma membrane
GO:0097225 IDA:UniProtKBCsperm midpiece
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004691 IDA:BHF-UCLFcAMP-dependent protein kinase activity
GO:0034237 IPI:BHF-UCLFprotein kinase A regulatory subunit binding
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0004712 IDA:MGIFprotein serine/threonine/tyrosine kinase activity
GO:0031625 IDA:UniProtKBFubiquitin protein ligase binding
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0034199 TAS:ReactomePactivation of protein kinase A activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0035584 TAS:BHF-UCLPcalcium-mediated signaling using intracellular calcium source
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0086064 TAS:BHF-UCLPcell communication by electrical coupling involved in cardiac conduction
GO:0071872 TAS:BHF-UCLPcellular response to epinephrine stimulus
GO:0071377 TAS:ReactomePcellular response to glucagon stimulus
GO:0071333 IDA:UniProtKBPcellular response to glucose stimulus
GO:0071374 IEA:EnsemblPcellular response to parathyroid hormone stimulus
GO:0051480 TAS:BHF-UCLPcytosolic calcium ion homeostasis
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0000086 TAS:ReactomePG2/M transition of mitotic cell cycle
GO:0006094 TAS:ReactomePgluconeogenesis
GO:0006006 TAS:ReactomePglucose metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 TAS:ReactomePintracellular signal transduction
GO:0001707 IEA:EnsemblPmesoderm formation
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:1901621 IEA:EnsemblPnegative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0001843 IEA:EnsemblPneural tube closure
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0018107 IEA:EnsemblPpeptidyl-threonine phosphorylation
GO:0071158 ISS:UniProtKBPpositive regulation of cell cycle arrest
GO:0046827 IEA:EnsemblPpositive regulation of protein export from nucleus
GO:0046777 IEA:EnsemblPprotein autophosphorylation
GO:0006468 NAS:UniProtKBPprotein phosphorylation
GO:0055117 TAS:BHF-UCLPregulation of cardiac muscle contraction
GO:0010881 TAS:BHF-UCLPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027 TAS:BHF-UCLPregulation of heart rate
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0045667 IDA:UniProtKBPregulation of osteoblast differentiation
GO:0061136 IDA:UniProtKBPregulation of proteasomal protein catabolic process
GO:0043393 TAS:BHF-UCLPregulation of protein binding
GO:0070613 IEA:EnsemblPregulation of protein processing
GO:0060314 TAS:BHF-UCLPregulation of ryanodine-sensitive calcium-release channel activity
GO:0050804 IEA:EnsemblPregulation of synaptic transmission
GO:2000810 IDA:UniProtKBPregulation of tight junction assembly
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0048240 ISS:UniProtKBPsperm capacitation
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0019433 TAS:ReactomePtriglyceride catabolic process
GO:0006833 TAS:ReactomePwater transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_75774Adaptive Immune System
REACT_267965Anchoring of the basal body to the plasma membrane
REACT_23887Aquaporin-mediated transport
REACT_268265Assembly of the primary cilium
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_15479Centrosome maturation
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_75790Cytokine Signaling in Immune system
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_15334DARPP-32 events
REACT_268156Degradation of GLI1 by the proteasome
REACT_267700Degradation of GLI2 by the proteasome
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_2203G2/M Transition
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_1665Glucagon signaling in metabolic regulation
REACT_1520Gluconeogenesis
REACT_723Glucose metabolism
REACT_264090Glycogen storage diseases
REACT_15526G-protein mediated events
REACT_268323Hedgehog 'off' state
REACT_604Hemostasis
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_602Lipid digestion, mobilization, and transport
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization from the centrosome
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_22258Metabolism of lipids and lipoproteins
REACT_21391Mitotic G2-G2/M phases
REACT_264430Myoclonic epilepsy of Lafora
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_264135Organelle biogenesis and maintenance
REACT_21310Phospholipase C-mediated cascade
REACT_15530PKA activation
REACT_1946PKA activation in glucagon signalling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_1525PKA-mediated phosphorylation of key metabolic factors
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_20593Post NMDA receptor activation events
REACT_23898Rap1 signalling
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_18325Regulation of insulin secretion
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_264508Signaling by Hedgehog
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_24023Vasopressin regulates renal water homeostasis via Aquaporins
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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