MGP Database

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MGP002415

Ontology/Pathway Information

Entrez Gene ID5567
Gene Nameprotein kinase, cAMP-dependent, catalytic, beta
Gene Symbol PRKACB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005952 TAS:UniProtKBCcAMP-dependent protein kinase complex
GO:0005813 IDA:UniProtKBCcentrosome
GO:0097546 IEA:EnsemblCciliary base
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 IEA:UniProtKB-SubCellCplasma membrane
GO:0005524 IDA:UniProtKBFATP binding
GO:0004691 IDA:UniProtKBFcAMP-dependent protein kinase activity
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0031625 IDA:UniProtKBFubiquitin protein ligase binding
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0034199 TAS:ReactomePactivation of protein kinase A activity
GO:0007188 TAS:UniProtKBPadenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0071377 TAS:ReactomePcellular response to glucagon stimulus
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006094 TAS:ReactomePgluconeogenesis
GO:0006006 TAS:ReactomePglucose metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 TAS:ReactomePintracellular signal transduction
GO:0051447 IEA:EnsemblPnegative regulation of meiotic cell cycle
GO:1901621 IEA:EnsemblPnegative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0001843 IEA:EnsemblPneural tube closure
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0070613 IEA:EnsemblPregulation of protein processing
GO:0097338 IEA:EnsemblPresponse to clozapine
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0019433 TAS:ReactomePtriglyceride catabolic process
GO:0006833 TAS:ReactomePwater transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_75774Adaptive Immune System
REACT_23887Aquaporin-mediated transport
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_15334DARPP-32 events
REACT_268156Degradation of GLI1 by the proteasome
REACT_267700Degradation of GLI2 by the proteasome
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_1665Glucagon signaling in metabolic regulation
REACT_1520Gluconeogenesis
REACT_723Glucose metabolism
REACT_264090Glycogen storage diseases
REACT_15526G-protein mediated events
REACT_268323Hedgehog 'off' state
REACT_604Hemostasis
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_602Lipid digestion, mobilization, and transport
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_22258Metabolism of lipids and lipoproteins
REACT_264430Myoclonic epilepsy of Lafora
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_15530PKA activation
REACT_1946PKA activation in glucagon signalling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_1525PKA-mediated phosphorylation of key metabolic factors
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_20593Post NMDA receptor activation events
REACT_23898Rap1 signalling
REACT_18325Regulation of insulin secretion
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_264508Signaling by Hedgehog
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_24023Vasopressin regulates renal water homeostasis via Aquaporins
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00310Corticotropin Activation of Cortisol Production
SMP00308Dopamine Activation of Neurological Reward System
SMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
SMP00343Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
SMP00354Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
SMP00322Vasopressin Regulation of Water Homeostasis
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