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MGP002415

UniProt Annotations

Entry Information
Gene Nameprotein kinase, cAMP-dependent, catalytic, beta
Protein EntryKAPCB_HUMAN
UniProt IDP22694
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Beta1; IsoId=P22694-1; Sequence=Displayed; Name=2; Synonyms=Beta2; IsoId=P22694-2; Sequence=VSP_017364; Name=3; Synonyms=Beta3; IsoId=P22694-3; Sequence=VSP_017369, VSP_017370; Note=Incomplete sequence.; Name=4; Synonyms=Beta4; IsoId=P22694-4; Sequence=VSP_017368, VSP_017371; Note=Incomplete sequence.; Name=5; Synonyms=Beta4ab; IsoId=P22694-5; Sequence=VSP_017366; Note=Incomplete sequence.; Name=6; Synonyms=Beta4abc; IsoId=P22694-6; Sequence=VSP_017365; Name=7; IsoId=P22694-7; Sequence=VSP_017367; Note=No experimental confirmation available.; Name=8; IsoId=P22694-8; Sequence=VSP_036556, VSP_036557; Name=9; IsoId=P22694-9; Sequence=VSP_043372; Note=No experimental confirmation available.; Name=10; IsoId=P22694-10; Sequence=VSP_017366, VSP_046238; Note=No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationActivated by cAMP.
FunctionMediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175}.
InteractionQ92917:GPKOW; NbExp=4; IntAct=EBI-5258763, EBI-746309; P08238:HSP90AB1; NbExp=2; IntAct=EBI-2679622, EBI-352572;
PtmAsn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively. {ECO:0000250}.
Sequence CautionSequence=BAD92426.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};
SimilarityBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. {ECO:0000305}.
SimilarityContains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Nucleus {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}.
SubunitA number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity). {ECO:0000250}.
Tissue SpecificityIsoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. {ECO:0000269|PubMed:11589697}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/prkacb/";
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