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MGP002417

Record overview

MGPD IDMGP002417
Gene ID5573
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase, cAMP-dependent, regulatory, type I, alpha
Gene Symbol PRKAR1A
SynonymsCAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1;
Alternate namescAMP-dependent protein kinase type I-alpha regulatory subunit; Carney complex type 1; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; protein kinase A type 1a regulatory subunit; tissue-specific extinguisher 1;
Chromosome17
Map Location17q24.2
SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
OrthologsView orthologs and multiple alignments for PRKAR1A

Proteins

cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Refseq ID:NP_001263218
Protein GI:443497964
UniProt ID:P10644
mRNA ID:NM_001276289
Length:381
RefSeq Status:
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAI
SAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSF
GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
 
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Refseq ID:NP_001265362
Protein GI:510025468
UniProt ID:P10644
mRNA ID:NM_001278433
Length:381
RefSeq Status:
Protein sequence is identical to GI:443497964 (mRNA isoform)
 
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Refseq ID:NP_997637
Protein GI:47132583
UniProt ID:P10644
mRNA ID:NM_212472
Length:381
RefSeq Status:
Protein sequence is identical to GI:443497964 (mRNA isoform)
 
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Refseq ID:NP_997636
Protein GI:47132581
UniProt ID:P10644
mRNA ID:NM_212471
Length:381
RefSeq Status:
Protein sequence is identical to GI:443497964 (mRNA isoform)
 
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Refseq ID:NP_002725
Protein GI:4506063
UniProt ID:P10644
mRNA ID:NM_002734
Length:381
RefSeq Status:
Protein sequence is identical to GI:443497964 (mRNA isoform)
 
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform b
Refseq ID:NP_001263219
Protein GI:443497966
UniProt ID:P10644
mRNA ID:NM_001276290
Length:337
RefSeq Status:
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAI
SAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSF
GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGHLIISRRSIPLG
 
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