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MGP002419

Record overview

MGPD IDMGP002419
Gene ID5576
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
Gene Symbol PRKAR2A
SynonymsPKR2; PRKAR2;
Alternate namescAMP-dependent protein kinase type II-alpha regulatory subunit; cAMP-dependent protein kinase regulatory subunit RII alpha; protein kinase A, RII-alpha subunit;
Chromosome3
Map Location3p21.3-p21.2
SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PRKAR2A

Proteins

cAMP-dependent protein kinase type II-alpha regulatory subunit
Refseq ID:NP_004148
Protein GI:4758958
UniProt ID:P13861
mRNA ID:NM_004157
Length:404
RefSeq Status:
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSV
CAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQY
DNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI
IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLG
NLGQ
 
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