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MGP002419

UniProt Annotations

Entry Information
Gene Nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
Protein EntryKAP2_HUMAN
UniProt IDP13861
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13861-1; Sequence=Displayed; Name=2; IsoId=P13861-2; Sequence=VSP_056821;
FunctionRegulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
InteractionP03259-2:- (xeno); NbExp=5; IntAct=EBI-2556122, EBI-7225021; Q92667:AKAP1; NbExp=3; IntAct=EBI-2556122, EBI-2119593; O75969:AKAP3; NbExp=2; IntAct=EBI-2556122, EBI-9033101;
PtmPhosphorylated by the activated catalytic chain. {ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:18318008, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the cAMP-dependent kinase regulatory chain family. {ECO:0000305}.
SimilarityContains 2 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
SubunitThe inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
Tissue SpecificityFour types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
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