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MGP Database

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MGP002420

UniProt Annotations

Entry Information

Gene Name	protein kinase, cAMP-dependent, regulatory, type II, beta
Protein Entry	KAP3_HUMAN
UniProt ID	P31323
Species	Human

Comments

Comment type	Description
Function	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Ptm	Phosphorylated by the activated catalytic chain. {ECO:0000269\|PubMed:18318008, ECO:0000269\|PubMed:19690332, ECO:0000269\|PubMed:21406692}.
Similarity	Belongs to the cAMP-dependent kinase regulatory chain family. {ECO:0000305}.
Similarity	Contains 2 cyclic nucleotide-binding domains. {ECO:0000255\|PROSITE-ProRule:PRU00060}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:21423175}. Cell membrane {ECO:0000269\|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
Subunit	The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2. {ECO:0000269\|PubMed:21423175}.
Tissue Specificity	Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.