MGP Database

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MGP002423

Ontology/Pathway Information

Entrez Gene ID5580
Gene Nameprotein kinase C, delta
Gene Symbol PRKCD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:UniProtKB-SubCellCmitochondrion
GO:0016363 IEA:EnsemblCnuclear matrix
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IEA:UniProtKB-SubCellCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004699 TAS:BHF-UCLFcalcium-independent protein kinase C activity
GO:0008047 IDA:UniProtKBFenzyme activator activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0043560 ISS:BHF-UCLFinsulin receptor substrate binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004715 IEA:UniProtKB-ECFnon-membrane spanning protein tyrosine kinase activity
GO:0004697 ISS:UniProtKBFprotein kinase C activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0006915 IDA:UniProtKBPapoptotic process
GO:0042100 IEA:EnsemblPB cell proliferation
GO:0007596 TAS:ReactomePblood coagulation
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0090398 IMP:BHF-UCLPcellular senescence
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0042742 ISS:UniProtKBPdefense response to bacterium
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0016064 IEA:EnsemblPimmunoglobulin mediated immune response
GO:0045087 TAS:ReactomePinnate immune response
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0032613 IEA:EnsemblPinterleukin-10 production
GO:0032615 IEA:EnsemblPinterleukin-12 production
GO:0008631 TAS:ParkinsonsUK-UCLPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0030837 ISS:UniProtKBPnegative regulation of actin filament polymerization
GO:0051490 ISS:UniProtKBPnegative regulation of filopodium assembly
GO:0034351 IMP:UniProtKBPnegative regulation of glial cell apoptotic process
GO:0050728 IC:BHF-UCLPnegative regulation of inflammatory response
GO:0046627 ISS:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0043407 IMP:BHF-UCLPnegative regulation of MAP kinase activity
GO:0050732 ISS:BHF-UCLPnegative regulation of peptidyl-tyrosine phosphorylation
GO:0090331 ISS:UniProtKBPnegative regulation of platelet aggregation
GO:0032091 TAS:BHF-UCLPnegative regulation of protein binding
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0042119 IDA:UniProtKBPneutrophil activation
GO:0018107 IDA:UniProtKBPpeptidyl-threonine phosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:2001235 IEA:EnsemblPpositive regulation of apoptotic signaling pathway
GO:2000304 IMP:BHF-UCLPpositive regulation of ceramide biosynthetic process
GO:2000753 IMP:BHF-UCLPpositive regulation of glucosylceramide catabolic process
GO:1900163 IMP:UniProtKBPpositive regulation of phospholipid scramblase activity
GO:0035307 IMP:BHF-UCLPpositive regulation of protein dephosphorylation
GO:2001022 IMP:UniProtKBPpositive regulation of response to DNA damage stimulus
GO:2000755 IMP:BHF-UCLPpositive regulation of sphingomyelin catabolic process
GO:0032930 IMP:UniProtKBPpositive regulation of superoxide anion generation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0050821 NAS:UniProtKBPprotein stabilization
GO:0010469 TAS:BHF-UCLPregulation of receptor activity
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0007165 TAS:ReactomePsignal transduction
GO:0023021 IMP:BHF-UCLPtermination of signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_75790Cytokine Signaling in Immune system
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_2202Effects of PIP2 hydrolysis
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18283G alpha (q) signalling events
REACT_19333G alpha (z) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_71Gene Expression
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_604Hemostasis
REACT_25218HuR stabilizes mRNA
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_798Platelet activation, signaling and aggregation
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_268456Programmed Cell Death
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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