MGP Database

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MGP002435

Ontology/Pathway Information

Entrez Gene ID5594
Gene Namemitogen-activated protein kinase 1
Gene Symbol MAPK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005901 TAS:UniProtKBCcaveola
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005856 TAS:UniProtKBCcytoskeleton
GO:0005829 TAS:UniProtKBCcytosol
GO:0032839 IEA:EnsemblCdendrite cytoplasm
GO:0005769 TAS:UniProtKBCearly endosome
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 TAS:UniProtKBCfocal adhesion
GO:0005794 TAS:UniProtKBCGolgi apparatus
GO:0005770 TAS:UniProtKBClate endosome
GO:0015630 IDA:HPACmicrotubule cytoskeleton
GO:0005815 IEA:UniProtKB-SubCellCmicrotubule organizing center
GO:0005739 TAS:UniProtKBCmitochondrion
GO:0072686 ISS:UniProtKBCmitotic spindle
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043204 IEA:EnsemblCperikaryon
GO:0043234 IEA:EnsemblCprotein complex
GO:0031143 IEA:EnsemblCpseudopodium
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003677 IEA:UniProtKB-KWFDNA binding
GO:0004707 TAS:ProtIncFMAP kinase activity
GO:0019902 IPI:UniProtKBFphosphatase binding
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0008353 ISS:UniProtKBFRNA polymerase II carboxy-terminal domain kinase activity
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0050853 IEA:EnsemblPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0072584 TAS:UniProtKBPcaveolin-mediated endocytosis
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0006974 IEA:EnsemblPcellular response to DNA damage stimulus
GO:0097011 IEA:EnsemblPcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0006935 TAS:ProtIncPchemotaxis
GO:0019858 IEA:EnsemblPcytosine metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038127 IDA:UniProtKBPERBB signaling pathway
GO:0070371 IDA:UniProtKBPERK1 and ERK2 cascade
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060716 IEA:EnsemblPlabyrinthine layer blood vessel development
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0033598 IEA:EnsemblPmammary gland epithelial cell proliferation
GO:0000165 TAS:ReactomePMAPK cascade
GO:0000189 IEA:EnsemblPMAPK import into nucleus
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0045596 IEA:EnsemblPnegative regulation of cell differentiation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 IEA:EnsemblPorgan morphogenesis
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0018107 ISS:UniProtKBPpeptidyl-threonine phosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0010800 IDA:UniProtKBPpositive regulation of peptidyl-threonine phosphorylation
GO:0045893 IEA:EnsemblPpositive regulation of transcription, DNA-templated
GO:0045727 IEA:EnsemblPpositive regulation of translation
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0051493 TAS:UniProtKBPregulation of cytoskeleton organization
GO:2000641 TAS:UniProtKBPregulation of early endosome to late endosome transport
GO:0090170 TAS:UniProtKBPregulation of Golgi inheritance
GO:0031647 ISS:UniProtKBPregulation of protein stability
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0032872 TAS:UniProtKBPregulation of stress-activated MAPK cascade
GO:0070849 IDA:UniProtKBPresponse to epidermal growth factor
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0043330 IEA:EnsemblPresponse to exogenous dsRNA
GO:0006950 TAS:ProtIncPresponse to stress
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0019233 IEA:EnsemblPsensory perception of pain
GO:0007165 TAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0050852 IEA:EnsemblPT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_21326Activation of the AP-1 family of transcription factors
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_15307Ca-dependent events
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_263897Cellular response to heat stress
REACT_169274Cellular Senescence
REACT_20568CREB phosphorylation through the activation of Ras
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1183ERK2 activation
REACT_1482ERK activation
REACT_12599ERK/MAPK targets
REACT_12436ERKs are inactivated
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_1100Golgi Cisternae Pericentriolar Stack Reorganization
REACT_15526G-protein mediated events
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_111133Growth hormone receptor signaling
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_22205L1CAM interactions
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_111184Negative regulation of FGFR signaling
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_169325Oncogene Induced Senescence
REACT_15295Opioid Signalling
REACT_169436Oxidative Stress Induced Senescence
REACT_15466phospho-PLA2 pathway
REACT_798Platelet activation, signaling and aggregation
REACT_15426PLC beta mediated events
REACT_20593Post NMDA receptor activation events
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_22365Recycling pathway of L1
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_264487Regulation of HSF1-mediated heat shock response
REACT_20510RSK activation
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_508Signal attenuation
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
REACT_524SOS-mediated signalling
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_13477Transmission across Chemical Synapses
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00391Insulin Signalling
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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