MGP Database

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MGP002446

Ontology/Pathway Information

Entrez Gene ID5607
Gene Namemitogen-activated protein kinase kinase 5
Gene Symbol MAP2K5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IEA:EnsemblCcytosol
GO:0005634 IEA:EnsemblCnucleus
GO:0005819 IEA:EnsemblCspindle
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IEA:UniProtKB-KWFprotein serine/threonine kinase activity
GO:0004713 IEA:UniProtKB-KWFprotein tyrosine kinase activity
GO:0000187 ISS:BHF-UCLPactivation of MAPK activity
GO:0071363 ISS:BHF-UCLPcellular response to growth factor stimulus
GO:0071499 TAS:BHF-UCLPcellular response to laminar fluid shear stress
GO:0070375 IEA:EnsemblPERK5 cascade
GO:0007507 IEA:EnsemblPheart development
GO:0090051 ISS:BHF-UCLPnegative regulation of cell migration involved in sprouting angiogenesis
GO:2000342 ISS:BHF-UCLPnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO:0043154 ISS:BHF-UCLPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001240 ISS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0034115 ISS:BHF-UCLPnegative regulation of heterotypic cell-cell adhesion
GO:0045415 ISS:BHF-UCLPnegative regulation of interleukin-8 biosynthetic process
GO:0032088 ISS:BHF-UCLPnegative regulation of NF-kappaB transcription factor activity
GO:0060761 ISS:BHF-UCLPnegative regulation of response to cytokine stimulus
GO:0000122 ISS:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030307 IEA:EnsemblPpositive regulation of cell growth
GO:0050679 IEA:EnsemblPpositive regulation of epithelial cell proliferation
GO:0051247 ISS:BHF-UCLPpositive regulation of protein metabolic process
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_11061Signalling by NGF
REACT_12020Signalling to ERK5
REACT_111102Signal Transduction
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