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MGP002446

UniProt Annotations

Entry Information
Gene Namemitogen-activated protein kinase kinase 5
Protein EntryMP2K5_HUMAN
UniProt IDQ13163
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=B; IsoId=Q13163-1; Sequence=Displayed; Name=A; IsoId=Q13163-2; Sequence=VSP_021825; Name=C; IsoId=Q13163-3; Sequence=VSP_021825, VSP_021826; Note=Incomplete sequence.; Name=4; IsoId=Q13163-4; Sequence=VSP_043333; Note=No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
DomainBinds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity). {ECO:0000250}.
FunctionActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.
InteractionP62993:GRB2; NbExp=2; IntAct=EBI-307294, EBI-401755; Q99759:MAP3K3; NbExp=2; IntAct=EBI-307294, EBI-307281; Q13164:MAPK7; NbExp=2; IntAct=EBI-307294, EBI-1213983;
PtmActivated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.
PtmYersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:19369195, ECO:0000269|PubMed:7759517}.
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.
SimilarityContains 1 OPR domain. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SubunitInteracts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ. {ECO:0000250, ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517, ECO:0000269|Ref.13, ECO:0000269|Ref.14}.
Tissue SpecificityExpressed in many adult tissues. Abundant in heart and skeletal muscle.
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