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MGP002447

Record overview

MGPD IDMGP002447
Gene ID5608
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase kinase 6
Gene Symbol MAP2K6
SynonymsMEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3;
Alternate namesdual specificity mitogen-activated protein kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MEK 6; SAPK kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); stress-activated protein kinase kinase 3;
Chromosome17
Map Location17q24.3
EC Number2.7.12.2
SummaryThis gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MAP2K6

Proteins

dual specificity mitogen-activated protein kinase kinase 6
Refseq ID:NP_002749
Protein GI:14589900
UniProt ID:P52564
mRNA ID:NM_002758
Length:334
RefSeq Status:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL
DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI
SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
 
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