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MGP002459

UniProt Annotations

Entry Information
Gene Namephosphoribosyl pyrophosphate synthetase 2
Protein EntryPRPS2_HUMAN
UniProt IDP11908
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11908-1; Sequence=Displayed; Name=2; IsoId=P11908-2; Sequence=VSP_027769; Note=No experimental confirmation available.;
Catalytic ActivityATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationActivated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3- bisphosphoglyceride or GDP.
FunctionCatalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
PathwayMetabolic intermediate biosynthesis; 5-phospho-alpha-D- ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1- diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Sequence CautionSequence=AAH30019.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ribose-phosphate pyrophosphokinase family. {ECO:0000305}.
SubunitHomodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity). {ECO:0000250}.
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